Optimizing supercritical antisolvent process parameters to minimize the particle size of paracetamol nanoencapsulated in L-polylactide

Optimizing supercritical antisolvent process parameters to minimize the particle size of paracetamol nanoencapsulated in L-polylactide

Blog Article

Mahshid Kalani, Robiah Yunus, Norhafizah AbdullahChemical and Environmental Engineering, Faculty of Engineering, University Putra Malaysia, Selangor Darul Ehsan, MalaysiaBackground: The aim of this study was to optimize the different process parameters including pressure, temperature, and polymer concentration, to produce fine small spherical particles with a narrow particle size distribution using a supercritical antisolvent method for drug encapsulation.The interaction between different process parameters was also investigated.Methods and results: PROMASIL CHOCOLATE The optimized process parameters resulted in production of nanoencapsulated paracetamol in L-polylactide with a mean diameter of approximately 300 nm at 120 bar, 30°C, and a polymer concentration of 16 ppm.Thermogravimetric analysis illustrated the thermal characteristics of the nanoparticles.The high electrical charge Tap Y-Adaptor on the surface of the nanoparticles caused the particles to repel each other, with the high negative zeta potential preventing flocculation.

Conclusion: Our results illustrate the effect of different process parameters on particle size and morphology, and validate results obtained via RSM statistical software.Furthermore, the in vitro drug-release profile is consistent with a Korsmeyer–Peppas kinetic model.Keywords: supercritical, antisolvent, encapsulation, nanoparticles, biodegradable polymer, optimization, drug delivery.